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Methods of Use
Street users usually inject opiate solutions under the skin (‘skin popping’) or directly into a vein or muscle, but the drugs may also be ‘snorted’ into the nose or taken orally or rectally.

Effects of Use
The effects of any drug depend on several factors:
the amount taken at one time; the user’s past drug experience; the manner in which the drug is taken; and the circumstances under which the drug is taken (the place, the user’s psychological and emotional stability, the presence of other people, simultaneous use of alcohol or other drugs, etc.).

Immediate
These appear soon after a single dose and disappear in a few hours or days. Opiates and opioids briefly stimulate the higher centres of the brain but then depress activity of the central nervous system. Immediately after injection into a vein, the user feels a surge of pleasure or a ‘rush’. This gives way to a state of gratification – hunger, pain, and sexual urges rarely intrude.

The dose required to produce these effects may at first cause restlessness, nausea, and vomiting. With moderately high doses, however, the body feels warm, the extremities heavy, and the mouth dry. Soon, the user goes ‘on the nod’, an alternately wakeful and drowsy state during which the world is forgotten.

As the dose is increased, breathing becomes gradually slower. With very large doses, the user cannot be roused; the pupils contract to pinpoints; the skin is cold, moist, and bluish; and profound respiratory depression resulting in death may occur.

Long Term
These appear after repeated use over a long period. Chronic opiate users may develop endocarditis, an infection of the heart lining and valves as a result of non-sterile injection techniques.

Drug users who share needles are also at a high risk of acquiring AIDS (acquired immune deficiency syndrome) and HIV infection (human immunodeficiency virus). Non-sterile injection techniques can also cause abscesses, cellulitis, liver disease, and even brain damage. Among users with a long history of subcutaneous injection, tetanus is common. Pulmonary complications, including various types of pneumonia, may also result from the unhealthy lifestyle of the user, as well as from the depressant effect of opiates on respiration.

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